杂志文章投稿 pre submission inquiry (投稿前咨询) 2023-10-10 paper submission 文献写作素材积累 积累文献中各种常用词汇,词组和句型句式 2022-09-29 paper vacabulary 文献阅读 Day16 通过氨基酸序列预测重要的外显子原文:Predicting exon criticality from protein sequence 杂志:NAR 对于exon的可变剪接事件(AS),通常是通过 RNA-seq 测序进行寻找检测。这篇文章 2022-03-06 paper exon prediction software 文献阅读 Day15 同义突变通过影响剪接来调控下游事件,从而在癌症中发挥作用Silent mutations reveal therapeuticvulnerability in RAS Q61 cancers 同义突变尽管不影响氨基酸的编码,但在 RNA 水 2022-03-05 paper tumor mutation 文献阅读 Day13 RBP TDP-43 抑制了神经退行性疾病 FTD-ALS 中基因 UNC13A 的 cryptic exon(CE) 的保留TDP-43 represses cryptic exon inclusion in the FTD–ALS ge 2022-02-26 paper RBP 文献阅读 Day12 Intron 的不同命运Differential fates of introns in gene expression due to globalalternative splicing 这篇 review 主要介绍了 intron 2022-02-25 paper intron 文献阅读 Day11 CLIP-seq 中鉴定出的 circRNA-binding eventsHCRNet:high-throughputcircRNA-bindingeventidentificationfromCLIP-seqdatausingdeepte 2022-02-23 paper CLIP RBP circRNA 基因组范围的 CRISPR-Cas9 对剪接网络的研究揭示了与自闭症相关的 microexon 识别 原文:Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated 2022-02-22 paper RBP microexon 文献阅读 Day10 global screening 鉴定出 染色质富集的 RBP 和在单核细胞分化过程中 QKI5 的转录调节活性A global screening identifies chromatin-enriched RNA-binding pro 2022-02-20 paper RBP Che-RBP 文献阅读 Day9 对环形化的外显子剪接位点进行碱基编辑,可以达到敲除 circRNA 的效果Knockout of circRNAs by base editing back-splice sites of circularized exons 杂志: Ge 2022-02-19 paper circRNA 文献阅读 Day8 组蛋白修饰通过影响选择性剪接调节 EMT(epithelial-to-mesenchymal transition)Histone marks regulate the epithelial-to-mesenchymal transitio 2022-02-18 paper histone modification 文献阅读 Day7 RNA pairing 阻止了“先来先服务”的剪接原则,促进了果蝇中 Dscam1 多种转录本的产生Hidden RNA pairings counteract the “first-come, first-served” splicing 2022-02-17 paper RNA secondary structure